 Ultimate Travel Group
 - Offers a variety of golf and ski tour packages.- Uniglobe Pacific Travel
- Offers winter and summer packages in British Columbia.
- Up North
- Offers river trips, adventure tours, boat rentals, and accommodations in Canada.
- U.S. Dive Travel
- Offering vacations at dive resorts, luxury live-aboards, and customized eco-tours in many countries.
- UC Tours
- Specializing in African American tours.
- Ujamaa Travel
- Features tours through Tanzania, places to stay, and ecotourism information for worldwide destinations.
- UK Tours & Travel
- Offers themed group tours to the United States from the United Kingdom.
- UKcitytours.com
- Offers London sightseeing tours and excursions including the British Museum and Windsor Castle, as well as day trips to Edinburgh, Salisbury, York, and other United Kingdom cities.
- Ultima Thule Experiences
- Offers a variety of outdoor adventures in Scandinavia, Finland, Baltic States, Russia, Karelia, and Belo-Russia.
- Ultimate Africa Safaris
- Offers budget camping to lodge safaris.
- Ultimate Ascents
- Offers worldwide climbing, trekking, paragliding, and skiing courses.
- Ultimate Dive Travel
- Specializes in diving vacations.
- Ultimate Rivers
- Offering premier sportfishing adventures in SW Alaska, Kamchatka, Russia and beyond.
- Umarike Expedicones
- Offers Copper Canyon outdoor expeditions, mountain bike adventures, canyon trekking trips, small groups tours, and professional guiding.
- Umiak Outfitters
- Canoe, kayak, and snowshoe tours for all ages and abilities.
- Umkulu Adventures
- Adventure overland, safari, and rafting company in southern Africa that specialises in budget orientated outdoor adventure holidays for independent travellers.
- Uncharted Outposts International
- Offers custom adventures to remote private ranches, tented camps, and intimate lodges in Africa, Australia, and Argentina.
- Uncommon Journeys
- Luxury rail and ocean liner voyages.
- Undersea Expeditions
- Gay and lesbian scuba diving tours.
- Undersea Explorer
- Extended scuba diving trips to the Great Barrier Reef and Coral Sea ex Cairns, Australia.
- Undersea Hunter
- Offering liveaboard diving vacations around Cocos Island.
- Underwater Connection, The
- Specializing in scuba instruction, sales, and service.
- Underworld Scuba
- Diving & snorkeling adventures in Mexico.
- Undiscovered Country Tours
- Provider of road bicycle tours for adults exclusively in California. Undiscovered Country Tours are available throughout the year.
- UNH Continuing Education and Summer Session@
- Uni Crystal Holidays
- Offers trips within India, Nepal, and Bhutan.
- Uni Galapagos
- Offering Galapagos tours, cruises and diving tours, Amazon and adventure tours, trekking, and climbing.
- Unicorn Trails
- Specializes in horse riding holidays worldwide for all abilities.
- Unique Path Trekking and Expedition
- Experience high adventures against the magnificent backdrop of the Himalaya Mountains through Nepal, Tibet, Bhutan, and India.
- United Touring Company
- Destination management company providing tours, safaris, and lodges in South Africa, Zimbabwe, Kenya, Tanzania, Zanzibar, and Uganda.
- United Travel
- Specializes in trips to the Holy Land and religious sites in Europe.
- Unithai Travel
- Offers inbound and outbound travel services from Thailand to China, Hong Kong, Singapore, Japan, and Nepal.
- Unitours
- Providing Catholic tours and pilgrimages to the Holy Land, Israel, Greece, Italy, Marian Shrines throughout Europe.
- University Beach Club & U.B. Ski
- Providing college travel trips with destinations to Breckenridge, Colorado (Winter Break) and Cancun, Mexico (Spring Break).
- University Educational Travel, Inc.
- Offers professor-led small group tours focusing on art, history, architecture, theatre, and archaeology in Europe, China, and the Middle East.
- Untamed Africa
- Offers wildlife tours and safaris in Bostwana, Namibia, Tanzania, Zimbabwe, and South Africa. Includes photo gallery featuring specific safaris and contact details.
- Untamed African Safaris
- Specializies in African safaris, custom-made tours, and mobile photographic camping trips in Botswana and throughout Africa.
- Untamed Path
- Adventure tours through the mountains, rainforests, rivers, and cultures of South America.
- Untours
- Offers apartment-based European travel packages.
- Upper Missouri River Guides
- Guided float trips on Montana's Upper Missouri National Wild and Scenic River, along the Lewis and Clark trail.
- Upsala-Lenna Jernvag
- Museum railway (narrow gauge) in the middle part of Sweden. Timetables, information, and pictures.
- Upstream Anglers
- Private and customized fishing and scenic rafting trips.
- Urban Fish
- Offers PADI training and dive travel.
- Ursus Major
- Hunting, fishing, and adventure tours in central Norway.
- Uruguay Golf
- Offers course reviews and travel tour packages.
- USA Bus Charter
- Offers tour bus charter and rental, school bus service, and entertainer coach leasing nationwide.
- USA Raft
- Offers a variety of trips for all ages and levels of experience over rivers in West Virginia, Tennessee, and North Carolina.
- Usiba Safaris
- Big game hunting, wingshooting, and fishing safaris in South Africa.
- Utah National Park Tours
- Offers tours to Zion and Bryce National Parks and the Grand Canyon.
- Utan Bara Adventure Team
- Offers treks to wildlife sanctuaries and undeveloped jungle locations in Peninsular Malaysia.
- Utopia Tours
- Specializing in charter bus services, motorcoach, air and cruise, and Branson tours in the U.S.
- Uummannaq Tourist Service and Hotel
- Offers accommodation and excursions such as glacier boat trips, whale watching, a hike to Santa Claus's house, ice golfing, dog sledding, and more. In the Disko Bay Region, Greenland.
- UXU Ranch
- North-eastern Wyoming dude ranch, with horseback riding, fly-fishing, and gourmet dining.
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