- AMUR
 - Working to save Siberian tigers and leopards, whose habitat is the Russian Far East, two of the most endangered big cats on the planet. - Big Cat Rescue
- Offers information, news, photos and sounds. Provides education, care, events, guided tours, and more.
- Bridgeport Nature Center
- An educational wildlife park dedicated to helping preserve great cats of the world including African Lions, Bengal Tigers, Leopards, and Cougars.
- EARS: Endangered Animal Rescue Sanctuary
- Provides dignified living for endangered big cats.
- International Exotic Feline Sanctuary
- Offers guided tours of the bobcats, cougars, jaquars, leopards, lions, servals, tigers and other species they care for.
- Last Hope Animal Preserve
- Nonprofit sanctuary dedicated to the care and preservation of abused and neglected lions and tigers.
- T&D's Cats Of The World
- Refuge for large exotic felines including lions, tigers, cougars, and bobcats as well as other animals from private individuals, government agencies, zoos, and other refuge organizations.
- Thunderhawk Enterprises, Inc.
- Volunteer organization dedicated to the rescue and preservation of big cats.
- Tiger Creek Wildlife Refuge (TCWR)
- Located in East Texas, it provides rescue and rehabilitation for big cats that have been abused, neglected, or displaced.
- Tiger Haven
- Rescues and provides a permanent home for big cats who have been confiscated, abused, or are no longer able to remain in their current home.
- Turpentine Creek Wildlife Refuge and Foundation
- USDA licensed, nonprofit organization dedicated to rescuing and preserving endangered large carnivores, with a focus on tigers, lions, cougars, and leopards.
- Wild About Cats
- Big cat rescue, conservation, and education.
- Wildcat Sanctuary, The
- Facilitates the humane rescue of unwanted or mistreated and neglected privately owned wildcats.
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