- Avalanche Scalable Multiprocessor Design Project
 - Aimed at the significant reduction of effective memory latency in support of both cache-coherent Distributed Shared Memory and Message Passing applications. - Caltech Infospheres Group
- Deals with the theory and implementation of compositional systems that support peer-to-peer communication among persistent multithreaded distributed objects.
- ClimatePrediction.net
- Encourages PC users to download a screensaver-style climate modelling program that will help generate the world's largest climate forecasting experiment.
- Compute Against Cancer
- Philanthropic distributed computing effort spanning research in cancer prevention, treatment, cure, and support.
- Distributed.net - Project RC5
- Mailing list archives and discussion groups.
- DOE Science Grid
- Objective is to provide the advanced distributed computing infrastructure based on Grid middleware and tools to enable the degree of scalability in scientific computing necessary for DOE to accomplish its missions in science.
- Fight AIDS @ Home
- Distributed computing project which uses idle computer time on your personal computer to accelerate anti-HIV drug design research. Download a program onto your Internet-connected home workstation to participate.
- Find-a-Drug
- Runs a series of projects in parallel addressing a number of diseases and utilizes THINK software to help evaluate the interactions of billions of molecules with proteins.
- Folding@home
- Distributed client aimed at using idle CPU power via a screen saver to help simulate protein folding.
- Genome@home
- Distributed computing project to understand the genome by reverse engineering new protein sequences for existing folds. Led by the Pande Group at Stanford University.
- Globus Project, The
- Developing basic software infrastructure for computations that integrate geographically distributed computational and information resources.
- Grub
- Open source, distributed Internet crawler.
- In-silico Screening for Anthrax Toxin Inhibitors@
- Massachusetts Institute of Technology (MIT) - Alewife Project
- Large-scale multiprocessor that integrates cache-coherent, distributed shared memory, and user-level message-passing in a single integrated hardware framework.
- Millipede Project
- Developing technologies for high performance, virtual parallel machines in distributed environments.
- Particle Physics Data Grid
- Collaboration formed to enable the worldwide distributed computing model of current and future high-energy and nuclear physics experiments.
- SETI@home@
- World Community Grid
- Project to create the largest public computing grid benefiting humanity.
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